Journal: NPJ Parkinson's Disease

Article Title: Added value of a wrist-worn device for assessing tremor in Parkinson’s disease: reliability and validity of tremor evaluation at home

doi: 10.1038/s41531-025-01163-0

Figure Lengend Snippet: A amplitude, B duration, C volume with clinically observed amplitude and D volume with clinically observed constancy. Amplitude and volume values are presented after being Box-Cox transformed. Duration is presented untransformed. All statistical analyses were performed on Box-Cox transformed data. Dashed line indicates the threshold to identify the presence of tremor based on the ROC analysis. Statistically significant comparison groups based on clinical assessment, with Tukey HSD correction, and between people self-reporting tremor or no tremor are indicated; *p < 0.05, **p < 0.01, ***p < 0.001; ROC Receiver Operator Curve, UPDRS III Movement Disorder Society Unified Parkinson’s Disease Rating Scale, part III.

Article Snippet: Statistically significant comparison groups based on clinical assessment, with Tukey HSD correction, and between people self-reporting tremor or no tremor are indicated; *p < 0.05, **p < 0.01, ***p < 0.001; ROC Receiver Operator Curve, UPDRS III Movement Disorder Society Unified Parkinson’s Disease Rating Scale, part III.

Techniques: Transformation Assay, Comparison

Journal: NPJ Parkinson's Disease

Article Title: Added value of a wrist-worn device for assessing tremor in Parkinson’s disease: reliability and validity of tremor evaluation at home

doi: 10.1038/s41531-025-01163-0

Figure Lengend Snippet: Small black dots represent the non-transformed tremor metric derived on a given day. Large black dots represent the average of the non-transformed tremor metric over 5 days. Vertical bars represent the range observed over 5 days per participant. Data is ordered based on tremor volume and stratified based on the maximum score of the rest, postural or kinetic tremor items of the MDS-UPDRS III [0–4]. The dashed line indicates the threshold for detecting the presence of tremor based on the ROC analysis. The vertical axis is square root transformed; ROC Receiver Operator Curve, MDS-UPDRS III Movement Disorder Society Unified Parkinson’s Disease Rating Scale, part III.

Article Snippet: Statistically significant comparison groups based on clinical assessment, with Tukey HSD correction, and between people self-reporting tremor or no tremor are indicated; *p < 0.05, **p < 0.01, ***p < 0.001; ROC Receiver Operator Curve, UPDRS III Movement Disorder Society Unified Parkinson’s Disease Rating Scale, part III.

Techniques: Transformation Assay, Derivative Assay

Journal: PLOS Neglected Tropical Diseases

Article Title: Immune checkpoint TIM-3 defines hyperactivated NK cells and predicts fatal outcome in severe fever with thrombocytopenia syndrome

doi: 10.1371/journal.pntd.0013928

Figure Lengend Snippet: (A) Representative flow cytometry plots showing TIM-3 expression on NK cells from healthy donors and SFTS patients. (B) Frequency of NK cells (CD3 ⁻ CD56⁺) among peripheral blood mononuclear cells (PBMCs) in healthy donors (N = 14), recovered SFTS patients (N = 17), and deceased SFTS patients (N = 4). (C) Frequency of TIM-3 ⁺ NK cells among total NK cells in the same cohorts. (D) Paired longitudinal analysis of peripheral TIM-3 + NK cell frequencies among NK cells in SFTS patients (N = 4) during the acute phase and approximately two weeks into recovery. Paired longitudinal analysis of soluble TIM-3 (E) , Galectin-9 (F) , TNF-α (G) , IFN-γ (H) in plasma of SFTS patients (N = 9) during the acute and recovery phase. Each dot represents an individual donor. Box plots show the full range (min to max). Statistical analysis was performed using Kruskal–Wallis H test for (B); one-way ANOVA with Tukey’s multiple comparisons test for (C) and paired t-test for (D-H). IFN-γ, interferon gamma; NK, natural killer; sGalectin-9, soluble Galectin-9; SFTS, severe fever with thrombocytopenia syndrome; TNF-α, tumor necrosis factor alpha.

Article Snippet: Based on the optimal cutoff derived from the Galectin-9 ROC curve, patients were stratified into high- and low-expression groups.

Techniques: Flow Cytometry, Expressing, Clinical Proteomics

Journal: PLOS Neglected Tropical Diseases

Article Title: Immune checkpoint TIM-3 defines hyperactivated NK cells and predicts fatal outcome in severe fever with thrombocytopenia syndrome

doi: 10.1371/journal.pntd.0013928

Figure Lengend Snippet: (A) Serum levels of soluble TIM-3 (sTIM-3) and Galectin-9 in healthy individuals (N = 10), recovered SFTS patients (N = 17), and deceased SFTS patients (N = 4). (B) Pearson correlation analysis between sTIM-3 levels, Galectin-9 levels, and the frequency of TIM-3 + NK cells among NK cells with clinical characteristics. (C) ROC curves of serum Galectin-9, sTIM-3, and the frequency of TIM-3 ⁺ NK cells in predicting fatal outcome in the same cohort. (D) ROC curves of serum Galectin-9 and sTIM-3 in the validation cohort (N = 104), with AUC, sensitivity, and specificity calculated using the Youden index. (E) Kaplan–Meier survival analysis stratified by high vs. low serum Galectin-9 levels in the validation cohort (N = 104), using the ROC-derived optimal cutoff. Statistical significance was assessed using the Mann-Whitney test for (A), and Pearson correlation analysis with the Benjamini-Hochberg correction for (B), DeLong’s test for (C-D) and the log-rank test for (E). sTIM-3, soluble T cell immunoglobulin and mucin domain-3; Gal-9, galectin-9; CCI, Charlson comorbidity index; PLT, platelet count; AST, aspartate aminotransferase; Cr, creatinine; ROC, receiver operating characteristic curve; AUC, area under the ROC curve.

Article Snippet: Based on the optimal cutoff derived from the Galectin-9 ROC curve, patients were stratified into high- and low-expression groups.

Techniques: Biomarker Discovery, Derivative Assay, MANN-WHITNEY